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Opus, our most intelligent model, outperforms its peers on most of the common evaluation benchmarks for AI systems, including undergraduate level expert knowledge (MMLU), graduate level expert reasoning (GPQA), basic mathematics (GSM8K), and more. It exhibits near-human levels of comprehension and fluency on complex tasks, leading the frontier of general intelligence.
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Plus reactions worked differently: they used T4 DNA polymerase, an enzyme with strong 3’ to 5’ exonuclease activity, meaning it can chew back the end of a DNA strand. In the presence of only one dNTP, T4 DNA polymerase would degrade each fragment from its 3’ end until it reached a nucleotide complementary to that dNTP, at which point the exonuclease activity would be inhibited. This ensured that all fragments in a given plus reaction ended with the same nucleotide.